Flavor Enhancer · CAS 5550-12-9 · EU E627
Disodium Guanylate
FDA status: GRAS. EU: Approved. No U.S. state has enacted a specific ban yet.
According to the U.S. Food and Drug Administration, Disodium Guanylate is classified GRAS by the FDA, and no U.S. state has moved to restrict it independently of federal policy. Its composite safety score is 4 out of 5 (Low Risk), and the European Union separately classifies it as approved. By tracked product count it ranks #36 of 417.
- #36 of 417 by tracked product prevalence
The verdict
Disodium Guanylate is classified GRAS by the FDA, and no U.S. state has moved to restrict it. By Open Food Facts product count it sits #36 of 417 among additives with tracked product presence (91st percentile).
- 4/5
- Low Risk
- GRAS
- FDA status
- #36 of 417
- product-prevalence rank
- 0
- state regulations
Product-footprint and regulatory snapshot
Disodium Guanylate: 1,378 tracked U.S. products (common band, #36 of 417) frame how often this additive appears on shelves.
| Property | Value | Source |
|---|---|---|
| Tracked Products | 1,378 · #36 of 417 | Open Food Facts (US) |
| FDA Status | GRAS | FDA SAFFA |
| EU Status | Approved | EC 1333/2008 |
| E-Number | E627 | EU additive register |
| CAS Number | 5550-12-9 | CAS Registry |
| Category | Flavor Enhancer | FDA functional class |
| Composite Safety Score | 4 / 5 (Low Risk) | PlainIngredients methodology |
| EFSA ADI | Not established | EFSA scientific opinion |
| U.S. State Actions | 0 states | State legislative records |
Values reflect official agency classifications as published by the U.S. Food and Drug Administration and the European Union's regulatory framework. See our methodology for scoring details.
What is Disodium Guanylate?
Nucleotide flavor enhancer, paired with MSG.
Health Concerns
- Safe. Avoid with gout (purines).
Common Uses
Shelf-footprint peer axes
Nationwide peers for a common OFF footprint
Nearest OFF product-count peers (1,378 tracked here); safety-score column omitted on prevalence-led pages.
Nearest OFF product count to 1,378
Nearest other additives by Open Food Facts product count (floored at ≥50).
Frequently Asked Questions
Is Disodium Guanylate safe to consume?
Disodium Guanylate scores 4/5 (Low Risk). FDA status is GRAS. On the Open Food Facts U.S. sample it is a common additive (1,378 tracked products, #36 of 417), so product footprint, not just the score label, frames how widely a shopper will meet it.
What is Disodium Guanylate used for in food?
Disodium Guanylate shows up as Chips, noodles, seasoning mixes in the Flavor Enhancer class, and the OFF sample puts it in the common footprint band (1,378 products).
Where does Disodium Guanylate sit among food additives PlainIngredients tracks?
Among additives with at least one tracked product, it ranks #36 of 417 by Open Food Facts product count. See /methodology#corpus-placement for the ranking bases.
What is the difference between FDA and EU regulation of Disodium Guanylate?
The FDA classifies Disodium Guanylate as "GRAS" while the EU status is "Approved" (E627). The EU often applies the precautionary principle, sometimes restricting additives that remain approved in the US.
What health concerns are associated with Disodium Guanylate?
Research has identified the following health concerns for Disodium Guanylate: Safe. Avoid with gout (purines).. These findings inform its safety score of 4/5. Consult a healthcare provider for personalized guidance, especially if you have pre-existing conditions.